London: Friday, December 29, 2017: For information purposes, Hutchison China MediTech Limited (“Chi-Med”) (AIM/Nasdaq: HCM) hereby notifies the market that as at December 29, 2017, the issued share capital of Chi-Med consisted of 66,447,037 ordinary shares of US$1.00 each, with each share carrying one right to vote and with no shares held in treasury.
The above figure of 66,447,037 may be used by shareholders as the denominator for the calculations by which they could determine if they are required to notify their interest in, or a change to their interest in, Chi-Med under the Financial Conduct Authority’s Disclosure Rules and Transparency Rules.
For illustrative purposes only, the 66,447,037 ordinary shares would be equivalent to 66,447,037 CREST depositary interests (each equating to one ordinary share) which are traded on AIM or, if the CREST depositary interests were converted in their entirety, equivalent to 132,894,074 American depositary shares (each equating to one-half of one ordinary share) which are traded on Nasdaq.
Chi-Med is an innovative biopharmaceutical company which researches, develops, manufactures and sells pharmaceuticals and healthcare products. Its Innovation Platform, Hutchison MediPharma Limited, focuses on discovering and developing innovative therapeutics in oncology and autoimmune diseases for the global market. Its Commercial Platform manufactures, markets and distributes prescription drugs and consumer health products in China.
Chi‑Med is majority owned by the multinational conglomerate CK Hutchison Holdings Limited (SEHK: 1). For more information, please visit: www.chi‑med.com.
Mark Lee, Senior Vice President, Corporate Finance & Development
+852 2121 8200
Anthony Carlisle, Citigate Dewe Rogerson
+44 7973 611 888 (Mobile)
anthony.carlisle@cdrconsultancy.co.uk
Brad Miles, BMC Communications
+1 (917) 570 7340 (Mobile)
bmiles@bmccommunications.com
Susan Duffy, BMC Communications
+1 (917) 499 8887 (Mobile)
sduffy@bmccommunications.com
Matt Beck, The Trout Group
+1 (917) 415 1750 (Mobile)
mbeck@troutgroup.com
David Dible, Citigate Dewe Rogerson
+44 7967 566 919 (Mobile)
david.dible@citigatedewerogerson.com
Richard Gray / Andrew Potts
+44 (20) 7886 2500
London: Friday, December 29, 2017: Hutchison China MediTech Limited (“Chi-Med”) (AIM/Nasdaq: HCM) announces the following blocklisting six monthly return:
| 1. | Name of applicant: | Hutchison China MediTech Limited |
| 2. | Name of scheme: | Hutchison China MediTech Limited Share Option Schemes |
| 3. | Period of return: | From June 29, 2017 to December 28, 2017 |
| 4. | Balance under scheme from previous return: | 1,329,927 ordinary shares of US$1 each |
| 5. | The amount by which the block scheme has been increased, if the scheme has been increased since the date of the last return: | Nil |
| 6. | Number of securities issued/allotted under scheme during period: | 24,928 ordinary shares of US$1 each |
| 7. | Balance under scheme not yet issued/allotted at end of the period: | 1,304,999 ordinary shares of US$1 each |
| 8. | Number and class of securities originally listed and the date of admission: | 2,560,606 ordinary shares of US$1 each admitted on June 26, 2007 |
| 9. | Total number of securities in issue at the end of the period: | 66,447,037 ordinary shares of US$1 each |
| Name of contact: | Christian Hogg | |
| Address of contact: | 21/F., Hutchison House, 10 Harcourt Road, Hong Kong | |
| Telephone number of contact: | +852 2121 8200 |
Chi-Med is an innovative biopharmaceutical company which researches, develops, manufactures and sells pharmaceuticals and healthcare products. Its Innovation Platform, Hutchison MediPharma Limited, focuses on discovering and developing innovative therapeutics in oncology and autoimmune diseases for the global market. Its Commercial Platform manufactures, markets and distributes prescription drugs and consumer health products in China.
Chi‑Med is majority owned by the multinational conglomerate CK Hutchison Holdings Limited (SEHK: 1). For more information, please visit: www.chi‑med.com.
Mark Lee, Senior Vice President, Corporate Finance & Development
+852 2121 8200
Anthony Carlisle, Citigate Dewe Rogerson
+44 7973 611 888 (Mobile)
anthony.carlisle@cdrconsultancy.co.uk
Brad Miles, BMC Communications
+1 (917) 570 7340 (Mobile)
bmiles@bmccommunications.com
Susan Duffy, BMC Communications
+1 (917) 499 8887 (Mobile)
sduffy@bmccommunications.com
Matt Beck, The Trout Group
+1 (917) 415 1750 (Mobile)
mbeck@troutgroup.com
David Dible, Citigate Dewe Rogerson
+44 7967 566 919 (Mobile)
david.dible@citigatedewerogerson.com
Richard Gray / Andrew Potts
+44 (20) 7886 2500
2017年12月15日：和黄医药今日宣布在美国启动呋喹替尼I期桥接临床试验。呋喹替尼是一种高选择性强效口服血管内皮生长因子受体（VEGFR）1,2及3的抑制剂。呋喹替尼在中国以结直肠癌、肺癌或胃癌为适应症的多项II期和III期临床研究均达到了主要终点。此次启动的是一项多中心开放标签的I期临床试验，旨在评估呋喹替尼在美国晚期实体瘤患者中的安全性、耐受性和药代动力学特性。首位受试者已于12月初接受给药治疗。该研究详情可登录clinicaltrials.gov，检索NCT03251378查看。
结直肠癌：2017年6月，中国食品药品监督管理总局（CFDA）受理呋喹替尼以晚期结直肠癌（CRC）为适应症的新药上市申请；2017年9月，CFDA公布因呋喹替尼具有明显临床价值而授予其优先审评的资格。呋喹替尼的新药上市申请基于一项在中国成功完成的III期关键性注册研究FRESCO。该研究共计纳入416名CRC患者，其结果于2017年6月5日在美国临床肿瘤学会年会上以口头报告的形式公布（clinicaltrials.gov 注册号 NCT02314819）。呋喹替尼的3项早期临床研究为FRESCO研究的开展奠定了基础，这3项早期临床研究包括：纳入40名实体瘤患者的I期临床研究、纳入62名结直肠癌患者的Ib期临床研究以及纳入71名结直肠癌患者的II期临床研究。
肺癌：呋喹替尼以三线治疗非小细胞肺癌（NSCLC）为适应症的III期关键性临床试验FALUCA（clinicaltrials.gov 注册号 NCT02691299）目前也正在中国展开，预计将纳入约520名患者。该研究基于一项纳入91名三线NSCLC患者的II期临床试验。另有一项II期临床试验也正在进行中，该试验以呋喹替尼联合易瑞沙®（吉非替尼）作为一线疗法，治疗晚期或转移性NSCLC（clinicaltrials.gov 注册号 NCT02976116）。
胃癌：呋喹替尼联合泰素®（紫杉醇）以晚期胃癌或胃食管结合部（GEJ）腺癌为适应症的III期关键性临床试验FRUTIGA（clinicaltrials.gov 注册号NCT03223376）已于2017年10月启动，预计将纳入超过500名患者。
在中国范围内，呋喹替尼由和黄医药和礼来合作开发。
呋喹替尼（HMPL-013）是一种新型的高选择性小分子候选药物。临床研究证实：通过一日一次的口服剂量即可有效的抑制血管内皮生长因子受体（VEGFR），且脱靶毒性低于其他靶向疗法。呋喹替尼良好的耐受性以及无药物间相互作用的特性，为其与其他癌症疗法相联合提供了理论支持，例如当前正在进行的呋喹替尼联合化疗或其他靶向治疗的临床研究。
癌症进入到晚期，肿瘤会分泌大量VEGFR的配体蛋白-血管内皮生长因子(VEGF)，以促进肿瘤组织周围形成大量的血管（血管生成），为肿瘤细胞的生长提供更多的血流、氧气和营养。VEGF和其受体VEGFR在肿瘤的血管生成中起到了至关重要的作用，而呋喹替尼可以抑制VEGF/VEGFR通路。对VEGF/VEGFR相关通路的抑制可以阻断肿瘤新生血管形成，从而成为防止肿瘤增长和入侵的一种重要的治疗策略。
Four Seasons Hotel, Hong Kong