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《柳叶刀 · 血液病学》：索乐匹尼布用于治疗中国原发免疫性血小板减少症患者

Sovleplenib (HMPL-523), a novel Syk inhibitor, for patients with primary immune thrombocytopenia in China: a randomised, double-blind, placebo-controlled, phase 1b/2 study Xiaofan Liu, Hu Zhou, Yu Hu, Jie Yin, Junmin Li, Wenming Chen, Ruibin Huang

科学出版物 | 2023-03-17

JSMO2023: 呋喹替尼治疗日本难治性转移性结直肠癌患者

The outcome for patients in Japan from the FRESCO-2 multi-regional clinical trial of fruquintinib, an oral inhibitor of VEGFR-1, -2 and -3, are being presented at the 2023 Japanese Society of Medical Oncology Annual Meeting, taking place March 16-18

科学出版物 | 2022-09-12

ESMO2022: FRESCO-2研究：一项旨在评估呋喹替尼用于治疗难治性的转移性结直肠癌患者的疗效和安全性的全球 III 期国际多中心临床试验

标题： FRESCO-2: A global Phase 3 multi-regional clinical trial (MRCT) evaluating the efficacy and safety of fruquintinib in patients with refractory metastatic colorectal cancer FRESCO-2研究: 一项旨在评估呋喹替尼用于治�

科学出版物 | 2022-06-06

ASCO2022: 索凡替尼在美国软组织肉瘤患者中的应用

Surufatinib in U.S. patients with soft tissue sarcoma Authors Sujana Movva, Alexander I. Spira, Erika P. Hamilton, Judy S. Wang, Allen Lee Cohn, James F. Strauss, Silvia Stacchiotti, Chris Tucci, John Kauh, Shivani Nanda, Marek K. Kania, Sh

科学出版物 | 2022-06-06

ASCO2022: 两项 Ⅲ 期临床试验中索凡替尼治疗晚期 NETs 患者的安全性汇总分析

A pooled analysis of surufatinib safety from phase 3 trials in advanced NETs Authors Jie Li, Jianming Xu, Lin Shen, Chunmei Bai, Zhiwei Zhou, Zhiping Li, Yihebali Chi, Xianjun Yu, Enxiao LI, Nong Xu, Tianshu Liu, Wenhui Lou, Yuxian Bai, Xia

科学出版物 | 2021-12-12

ASH 2021: 选择性口服Syk抑制剂HMPL-523治疗复发或难治性淋巴瘤患者的I期临床试验初步结果

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科学出版物 | 2021-11-03

NANETS 2021: 索凡替尼治疗美国神经内分泌瘤患者的中期分析结果

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科学出版物 | 2021-09-17

ESMO 2021：呋喹替尼与替雷利珠单抗联合疗法治疗晚期三阴性乳腺癌患者的Ib/II期研究

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标题: An open-label, phase Ib/II study to evaluate the safety and efficacy of fruquintinib in combination with tislelizumab in patients with advanced triple negative breast cancer 一项评估呋喹替尼与替雷利珠单抗联合疗法治

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演示文稿, 科学出版物 | 2021-06-22

《柳叶刀 · 呼吸医学》：赛沃替尼治疗MET 外显子14 跳跃突变的中国非小细胞肺癌患者

Once-daily savolitinib in Chinese patients with pulmonary sarcomatoid carcinomas and other non-small-cell lung cancers harbouring MET exon 14 skipping alterations: a multicentre, single-arm, open-label, phase 2 study Shun Lu, Jian Fang

科学出版物 | 2021-06-04

ASCO 2021: 多中心、开放标签的I期研究︰评估HMPL-306治疗伴有IDH突变的局部晚期或转移性实体瘤患者的安全性和耐受性

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标题: A multicenter open-label phase 1 study evaluating the safety and tolerability of HMPL-306 in patients with locally advanced or metastatic solid tumors with IDH mutations. 一项多中心、开放标签的I期研究︰评估HMPL-30

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科学出版物 | 2021-06-04

ASCO 2021: 索凡替尼联合替雷利珠单抗治疗晚期实体瘤患者的开放标签的Ib/II期临床研究

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标题: An open-label phase 1b/2 study of surufatinib in combination with tislelizumab in subjects with advanced solid tumors 索凡替尼联合替雷利珠单抗治疗晚期实体瘤患者的开放标签的Ib/II期临床研究主�

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科学出版物 | 2021-06-04

ASCO 2021: 索凡替尼治疗美国神经内分泌瘤患者的中期分析结果

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标题: Interim analysis results of surufatinib in U.S. patients with neuroendocrine tumors (NETs). 索凡替尼治疗美国神经内分泌瘤患者的中期分析结果主要作者: Scott Paulson, MD, Baylor Sammons Cancer Center

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科学出版物 | 2021-04-09

AACR 2021: 赛沃替尼在伴有MET外显子14跳变的NSCLC患者中II期研究的ctDNA 分析

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AACR 2021: ctDNA Analysis in the Savolitinib Phase II Study in NSCLC Patients Harboring METex14 Skipping Alterations Presenter/Authors: Yongfeng Yu, Yongxin Ren, Jian Fang, Lejie Cao, Zongan Liang, Qisen Guo, Sen Han, Zimei Ji, Ye Wang,

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演示文稿, 科学出版物 | 2021-01-15

ASCO-GI 2021: FRESCO-2 呋喹替尼国际III期结直肠癌研究

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FRESCO-2: A global phase 3 study of the efficacy and safety of fruquintinib in patients (pts) with metastatic colorectal cancer (mCRC) Arvind Dasari, James Yao, Alberto Sobrero, Takayuki Yoshino, William Schelman, Shivani Nanda, Caly Chien, Su-Fen

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演示文稿, 科学出版物 | 2020-12-05

ASH2020: 选择性口服PI3Kδ抑制剂HMPL-689治疗中国复发/难治性淋巴瘤患者的I期剂量递增研究结果

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标题： Results from a Phase 1 Dose Escalation Study of HMPL-689, a Selective Oral Phosphoinositide 3-Kinase-Delta Inhibitor, in Chinese Patients with relapsed/refractory (R/R) Lymphoma 选择性口服磷脂酰肌醇3-激酶亚型�

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演示文稿, 科学出版物 | 2020-09-21

《柳叶刀·肿瘤学》：索凡替尼SANET-p III期研究

Surufatinib in advanced pancreatic neuroendocrine tumours (SANET-p): a randomised, double-blind, placebo-controlled, phase 3 study Jianming Xu*, Lin Shen*, Chunmei Bai*, Wei Wang*, Jie Li, Xianjun Yu, Zhiping Li, Enxiao Li, Xianglin Yuan, Yihe

演示文稿, 科学出版物 | 2020-09-21

《柳叶刀·肿瘤学》：索凡替尼SANET-ep III期研究

Surufatinib in advanced extrapancreatic neuroendocrine tumours (SANET-ep): a randomised, double-blind, placebo-controlled, phase 3 study Jianming Xu*, Lin Shen*, Zhiwei Zhou, Jie Li, Chunmei Bai, Yihebali Chi, Zhiping Li, Nong Xu, Enxiao Li, T

演示文稿, 科学出版物 | 2020-09-20

ESMO2020: 索凡替尼治疗晚期胰腺神经内分泌瘤患者（SANET-p）

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标题：索凡替尼治疗晚期胰腺神经内分泌瘤患者（SANET-p）：随机、双盲、安慰剂对照的III期临床试验 (NCT02589821) 主要作者：中国人民解放军总医院第五医学中心消化肿瘤科主任 �

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演示文稿, 科学出版物 | 2020-09-18

ESMO2020: 呋喹替尼治疗晚期实体瘤患者的I/Ib期临床试验

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标题：呋喹替尼治疗晚期实体瘤患者的I/Ib期临床试验：难治性转移性结直肠癌剂量递增队列的初步结果主要作者： N. Arvind Dasari, Associate Professor, Department of Gastrointestinal (GI) Medical

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演示文稿, 科学出版物 | 2020-09-18

ESMO2020: 索凡替尼SANET-ep研究按Ki-67和原发肿瘤起源的亚组分析

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标题：索凡替尼治疗晚期高分化的非胰腺神经内分泌瘤的随机、安慰剂对照的III期临床试验（SANET-ep）按Ki-67和原发肿瘤起源的亚组分析主要作者：中山大学肿瘤防治中心胃胰科�

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演示文稿, 科学出版物 | 2020-04-27

AACR2020: 索凡替尼在中美患者中的药代动力学特征及安全性比较

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标题：索凡替尼在中美患者中的药代动力学特征及安全性比较报告人： Arvind Dasari 作者： A Dasari1, S Paulson2, E Hamilton3, J Wang4, M Sung5, G Falchook6, C Tucci7, K Li7, C Chien7, J Kauh7, M Kani

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演示文稿, 科学出版物 | 2020-04-27

AACR2020: 关于索凡替尼联合特瑞普利单抗治疗晚期实体瘤患者的I期临床研究

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标题：关于索凡替尼联合特瑞普利单抗治疗晚期实体瘤患者的I期临床研究报告人：曹彦硕作者：陆明1, 曹彦硕1, 龚继芳1, 孙宇2, 李洁1, 沈琳1. 1北京大学肿瘤医院恶性肿

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演示文稿, 科学出版物 | 2020-03-13

ENETS 2020 : 索凡替尼用于中国晚期非胰腺神经内分泌瘤患者的安全性和特殊不良事件：SANET-ep研究数据分析

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>> 相关报道 The previously reported SANET-ep trial (clinicaltrials.gov identifier NCT02588170) demonstrated that surufatinib significantly improves progression-free survival (“PFS”) in patients with advanced extrapancreatic (non-panc

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演示文稿, 科学出版物 | 2020-02-06

《柳叶刀·肿瘤学》奥希替尼与沃利替尼用于EGFR突变、MET扩增的非小细胞肺癌

Osimertinib plus savolitinib in patients with EGFR mutation-positive, MET-amplified, non-small-cell lung cancer after progression on EGFR tyrosine kinase inhibitors: interim results from a multicentre, open-label, phase 1b study Lecia V Sequist;

演示文稿, 科学出版物 | 2019-09-29

ESMO 2019: 索凡替尼用于治疗高分化的晚期非胰腺神经内分泌瘤患者的疗效和安全性

标题：索凡替尼用于治疗高分化的晚期非胰腺神经内分泌瘤患者的疗效和安全性：随机化的III期临床试验（SANET-ep）结果报告人：中国人民解放军总医院第五医学中心消化肿瘤科

演示文稿, 科学出版物 | 2019-09-21

CSCO 2019: FRESCO研究中手足皮肤反应的发生情况及与疗效的关系

报告2 FRESCO 研究中手足皮肤反应的发生情况及与疗效的关系报告人：白玉贤，哈尔滨医科大学附属肿瘤医院其他作者：李进，秦叔逵，徐瑞华，沈琳，徐建明，邓艳红，杨

演示文稿, 科学出版物 | 2019-09-19

CSCO 2019 : 呋喹替尼三线治疗中国转移性结直肠癌的III期临床研究（FRESCO）中的肝转移亚组分析

报告呋喹替尼三线治疗中国转移性结直肠癌的III 期临床研究（FRESCO）中的肝转移亚组分析报告人：秦叔逵，东部战区总医院（原八一医院）其他作者：李进，徐瑞华，沈琳

演示文稿, 科学出版物 | 2019-09-09

WCLC 2019: 呋喹替尼治疗晚期非小细胞肺癌（FALUCA）III期试验

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MA14.05 - A Randomized Phase III Trial of Fruquintinib Versus Placebo in Patients with Advanced Non-Small Cell Lung Cancer (FALUCA) Venue: IASLC 2019 World Conference on Lung Cancer in Barcelona, Spain Session:MA14 - The Adequate MTarget

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演示文稿, 科学出版物 | 2019-06-01

《Clinical Cancer Research》：索凡替尼在高分化神经内分泌瘤的使用

Surufatinib in advanced well-differentiated neuroendocrine tumors: a multicenter, 3 single-arm, open-label, phase Ib/II trial Jianming Xu, Jie Li, Chunmei Bai, Nong Xu, Zhiwei Zhou, Zhiping Li, Caicun Zhou, Ru Jia, Ming Lu, Yuejuan Cheng, Chenyu Mao

演示文稿, 科学出版物 | 2018-06-26

JAMA: Fruquintinib vs Placebo in Previously Treated Metastatic Colorectal Cancer

Effect of Fruquintinib vs Placebo on Overall Survival in Patients With Previously Treated Metastatic Colorectal Cancer The FRESCO Randomized Clinical Trial Jin Li; Shukui Qin; Rui-Hua Xu; Lin Shen; Jianming Xu; Yuxian Bai; Lei Yang; Yanhong Deng;

演示文稿, 科学出版物 | 2018-06-04

ASCO 2018: Colorectal cancer Q-TWiST with fruquintinib treatment in FRESCO

Quality-adjusted time without symptoms or toxicity (Q-TWiST) of patients with metastatic colorectal cancer treated with fruquintinib in FRESCO Presenter: Yu-Xian Bai Other Authors: Hongyan Li, Ning Wang, Xiaojun Guo, Wei Wang, Songhua F

演示文稿, 科学出版物 | 2018-06-04

ASCO 2018: Subgroup analysis by prior anti-VEGF or anti-EGFR target therapy in FRESCO

Presenter: Ruihua Xu Other Authors: Jin Li, Yu-Xian Bai, Yanhong Deng, Lei Yang, Haijun Zhong, Zhendong Chen, Hongming Pan, Weijian Guo, Yongqian Shu, Ying Yuan, Jianming Xu, Lin Shen, Ning Wang, Xin Wang, Haidong Chi, Jack Peng, Y

演示文稿, 科学出版物 | 2018-04-17

AACR 2018: MET gene copy number gains evaluated by NGS is more predictive than other methods to enrich for papillary RCC patients sensitive to savolitinib

4541 / 26 - MET gene copy number gains evaluated by NGS is more predictive than other methods to enrich for papillary RCC patients sensitive to savolitinib, a selective MET inhibitor Presenter/Authors M. M. Frigault1, S. Signoretti2, A. Markovets

演示文稿, 科学出版物 | 2018-03-23

ASCPT 2018: Fruquintinib Pharmacokinetics in Humans

Pharmacokinetics of Fruquintinib in Humans Venue: American Society for Clinical Pharmacology & Therapeutics Annual Meeting in Orlando, Florida, USA Abstract #: PII-116 Authors: Ke Li, Chen Yu, Yanmei Liu, Xiangkun Li, Sumei Xia, Jian Wa

演示文稿, 科学出版物 | 2018-03-12

Journal of Clinical Oncology: Phase II Trial of Fruquintinib in Patients with Advanced Nonsquamous NSCLC

Shun Lu, Jianhua Chang, Xiaoqing Liu, Jianhua Shi, You Lu, Wei Li, Jin-ji Yang, Jianying Zhou, Jie Wang, Tongtong An, Lei Yang, Zhe Liu, Xiangdong Zhou, Mo Chen, Ye Hua and Weiguo Su Abstract Purpose Patients with advanced non‒small-cell lung

演示文稿, 科学出版物 | 2018-02-24

ACOS 2018: Adverse Events of Special Interest Profiles and Time Courses of Fruquintinib in the FRESCO Trial

Venue: The 13th International Conference of the Asian Clinical Oncology Society in Chiang Mai, Thailand Abstract #: ABS093 Authors: Jin Li, Shukui Qin, Yuxian Bai, Yanhong Deng, Lei Yang, Zhendong Chen, Haijun Zhong, Rui-hua Xu, Hongming Pan,

演示文稿, 科学出版物 | 2018-02-20

ICTO2018: Phase Ib of Savolitinib and Durvalumab in Renal Cell Carcinoma (CALYPSO)

A Phase Ib Study of Durvalumab (MEDI4736) in Combination with Savolitinib in Patients with Metastatic Renal Cell Carcinoma S Vari1, B Szabados1, A GomezdeLiano1, K Mousa2, L Rammazzo2, A Prendergast2, T Powles1 1 Barts Health NHS Trust, Barts Can

演示文稿, 科学出版物 | 2017-10-17

WCLC 2017: Phase Ib/II savolitinib plus Iressa® in MET-driven NSCLC

OA 09.06 – A Phase Ib Trial of Savolitinib plus Gefitinib for Chinese Patients with EGFR-Mutant MET-Amplified Advanced NSCLC Jin-Ji Yang, Jian Fang, Y. Shu, J. Chang, G. Chen, J. He, W. Li, X. Liu, N. Yang, Caicun Zhou, J. Huang, L. Yang, A.A. Han

演示文稿, 科学出版物 | 2017-10-17

WCLC 2017: Phase Ib/II savolitinib plus Tagrisso® in MET-driven NSCLC

OA 09.03 – TATTON Ph Ib Expansion Cohort: Osimertinib plus Savolitinib for Pts with EGFR-Mutant MET-Amplified NSCLC after Progression on Prior EGFR-TKI Myung-Ju Ahn, Ji-Youn Han, Lecia V Sequist, Byoung Chul Cho, J.S. Lee, Sang-We Kim, W. Su, C. T

演示文稿, 科学出版物 | 2017-10-15

WCLC 2017: Phase II fruquintinib combination with Iressa in NSCLC

JCSE 01.12 – A Phase II study of fruquintinib in combination with gefitinib in stage IIIb/IV NSCLC patients harboring EGFR activating mutations (NCT02976116) Shun Lu, Jianying Zhou, Xiaomin Niu, Mo Chen, Hongyan Yin, Ye Hua, Weiguo Su Venue: IA

演示文稿, 科学出版物 | 2017-09-28

CSCO 2017: Savolitinib Phase Ib in c-MET Gastric Cancer

Phase Ib Trial of the Safety and Antitumor Activity of Savolitinib in Advanced Gastric Cancer Patients with Aberrant c-MET Jifeng Feng, Baorui Liu, Tianshu Liu, Nong Xu, Jianming Xu, Yunpeng Liu, Yuxian Bai, Jin Li, Wei Li, Chunmei Bai, Tao Zhang,

演示文稿, 科学出版物 | 2017-09-28

CSCO 2017: Theliatinib Phase I Results

Novel EGFR TKI Theliatinib: An Open Label, Dose Escalation Phase I Clinical Trial Lin Shen, Li Zhang, Hongyun Zhao, Wenfeng Fang, Jifang Gong Venue: Chinese Society of Clinical Oncology Annual Meeting Session: Esophageal Cancer Presenter: Jif

演示文稿, 科学出版物 | 2017-09-27

CSCO 2017: FRESCO In-Depth Analysis

In-depth Analysis of the FRESCO Study: a Randomized, Double-blind, Phase III Trial Evaluating the Efficacy and Safety of Fruquintinib in Patients with 3+ Line Advanced Colorectal Cancer Shukui QIN*, Jin LI*, Yuxian BAI, Yanhong DENG, Lei YANG, Zhen

演示文稿, 科学出版物 | 2017-09-27

CSCO 2017: Theliatinib Preclinical Study in Esophageal Cancer

Is EGFR a “feasible” target for advanced esophageal cancer treatment? Rongxin Ren, Shiming Fan, Linfang Wang,Min Cheng, Dongxia Shi, Wei Zhang,Renxiang Tang, Ying Yu, Longxian Jiao, Jun Ni, Haibin Yang, Huaqing Cai,Feng Zhou, Weihan Zhang, Wei

演示文稿, 科学出版物 | 2017-06-23

Journal of Clinical Oncology: Biomarker-Based Phase II Trial of Savolitinib in Patients With Advanced PRCC

Toni K. Choueiri, Elizabeth Plimack, Hendrik-Tobias Arkenau, Eric Jonasch, Daniel Y.C. Heng, Thomas Powles, Melanie M. Frigault, Edwin A. Clark, Amir A. Handzel, Humphrey Gardner, Shethah Morgan, Laurence Albiges, and Sumanta Kumar Pal Abstract Pur

演示文稿, 科学出版物 | 2017-06-05

ASCO 2017: Fruquintinib Phase III in Metastatic Colorectal Cancer (FRESCO)

A randomized, double-blind, placebo-controlled, multi-centered phase III trial comparing fruquintinib versus placebo plus best supportive care in Chinese patients with metastatic colorectal cancer (FRESCO) Venue: American Society of Clinical Oncol

演示文稿, 科学出版物 | 2017-06-05

ASCO 2017: Sulfatinib Phase II in Medullary and Differentiated Thyroid Cancer

A phase II multicenter trial of the multitargeted kinase inhibitor sulfatinib in advanced medullary thyroid cancer (MTC) and radioiodine (RAI)-refractory differentiated thyroid cancer (DTC) Venue: American Society of Clinical Oncology Annual Meeti

演示文稿, 科学出版物 | 2017-04-04

AACR 2017: Preclinical evaluation of sulfatinib, a novel angio-immuno kinase inhibitor targeting VEGFR, FGFR1 and CSF-1R kinases

Preclinical evaluation of sulfatinib, a novel angio-immuno kinase inhibitor targeting VEGFR, FGFR1 and CSF-1R kinases Authors: Jinghong Zhou, Jun Ni, Min Cheng, Na Yang, Junqing Liang, Liang Ge, Wei Zhang, Jianxing Tang, Qiaoling Sun, Fu Li, Jia Hu,

演示文稿, 科学出版物 | 2017-04-03

AACR 2017: Fruquintinib combinations with targeted therapies or immune checkpoint inhibitors in preclinical tumor models

Evaluation of fruquintinib, a potent and selective oral VEGFR inhibitor, in combination with targeted therapies or immune checkpoint inhibitors in preclinical tumor models Authors: Yongxin Ren, Qiaoling Sun, Jingwen Long, Shiming Fan, Renxiang Tang,

演示文稿, 科学出版物 | 2017-03-09

ENETS 2017: Sulfatinib Phase Ib/II in Advanced Neuroendocrine Tumors

An Open-Label Phase Ib/II Study of Sulfatinib in Patients with Advanced Neuroendocrine Tumors (NCT02267967) Authors: J.M. Xu, J. Li, C.M. Bai, N. Xu, Z.W. Zhou, Z.P. Li, C.C. Zhou, W. Wang, J. Li, C. Qi, Y. Hua, W.G. Su Summary: The current Phase