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Job Title: (Senior) Scientist, ADC
Location: Shanghai

 

Major Responsibilities and Duties

  • 负责创新抗体偶联药物(Antibody-Drug Conjugate, ADC)的药物发现，以及创新偶联技术平台的开发，包括项目立项和在研项目推进
  • 主要负责抗体偶联药物的研发工作，主要负责抗体偶联药物的偶联、纯化工艺和分析方法的开发，并参与抗体改造、接头设计及药物的选择和优化；
  • 完善ADC平台建设， 负责各实验步骤SOP的建立、管理与维护，支持与ADC相关的共同开发项目工作。

 

Requirements & Qualifications

  • 免疫学、分子生物学、细胞生物学等专业硕士/博士学历。
  • 具有2-3年以上抗体偶联药物早期项目研究经验者优先
  • 熟悉ADC的载荷、共轭化学和相关的分析方法
  • 有很强的项目执行力；
  • 熟悉ADC相关参数和数据库使用
  • 流利的英语写作和口语
  • 责任心强，踏实工作，具有良好的沟通能力及团队合作意识、具备创新精神

 

If interested, please forward your resume to Joycej@hutch-med.com

Job Title: Senior Director of Novel Antibody Group
Location: Shanghai

 

Major Responsibilities and Duties

  • Develop internal novel antibody technology platform, including but not limited to bispecific, multi-specific antibodies, etc. to ensure quality support to pipeline programs in engineering and characterizing novel molecules.
  • Lead a group of scientists to efficiently advance novel antibody programs, and feed high quality drug molecules to R&D pipeline.
  • Develop novel antibody formats to ensure proprietary position in the field.
  • Manage novel antibody portfolio to achieve company short term and long term goals.
  • Identify and maintain collaborations with top industrial partners and academic researchers to support novel antibody efforts.
  • Setup and manage CRO contracts to enable/supplement internal novel projects.

 

Qualifications

  • PhD with minimum 8 years of academic/industry experience in antibody/protein engineering.
  • Extensive knowledge in target biology. Expertise in target validation studies.
  • Experience in developing biochemical assays, cell-based function assays is a plus
  • Extensive experience in bi/multi-specific antibody engineering.
  • Knowledge and experience in oncology and immunology drug discovery is a plus
  • Critical thinker with good time management and delivery focus, able to independently design, accurately interpret complex scientific experiments and data.
  • Highly motivated self-starter, work effectively and able to excel within a matrix organization.

 

If interested, please forward your resume to Joycej@hutch-med.com

Job Title: Manager, Analytical R&D
Location: Shanghai

 

Primary

The primary function for this position is to oversee analytical development’s daily activities, such as method development and validation, analytical testing and stability program.
 

Responsibilities

  • Supervise a group of analytical development scientists, and give guidance in their method development and validation, analytical testing, process support, stability and product evaluation.
  • Review method validation plans and reports to assure that the methods meet requirements during different phases of product development.
  • Direct activities and design experiments toward troubleshooting/optimization of existing analytical methods when necessary.
  • Assure accurate and timely testing and reporting all results, issuing technical reports which include certification and validation data.
  • Provide guidance on analytical investigations of abnormal results.
  • Work in collaboration with other departments, e.g. Process, Formulations, Regulatory Affairs, Production, Supply Chain, etc, to support timely new product development and submissions.
  • Work with contract laboratories and collaborators.
  • Participate in selection, evaluation and development of new personnel.

 

Qualifications

  • PhD or Master Degree in Chemistry, Pharmaceutical Sciences or related fields. Master with over 8 years of experience and PhD with over 3 years of experience in the pharmaceutical analytical chemistry.
  • Working knowledge of major analytical techniques. Ability to train scientists on new techniques.
  • Strong experience with analytical development in pharmaceutical development, including method development, validation, stability and in-process control within CMC.
  • Familiar with pharmaceutical industry regulations and NMPA/FDA/ICH guidelines
  • Proven supervisory experience.
  • Good analytical skills in sorting information, formatting directions and problem solving.
  • Good communication skills and English language ability.

 
If interested, please forward your resume to yvonnew@hutch-med.com

Job Title: Director of Novel Antibody Group
Location: Shanghai

 

Major Responsibilities and Duties

  • Develop internal novel antibody technology platform, including but not limited to bispecific, multi-specific antibodies, etc. to ensure quality support to pipeline programs in engineering and characterizing novel molecules.
  • Lead a group of scientists to efficiently advance novel antibody programs, and feed high quality drug molecules to R&D pipeline.
  • Develop novel antibody formats to ensure proprietary position in the field.
  • Manage novel antibody portfolio to achieve company short term and long term goals.
  • Identify and maintain collaborations with top industrial partners and academic researchers to support novel antibody efforts.
  • Setup and manage CRO contracts to enable/supplement internal novel projects.

 

Qualifications:

  • PhD with minimum 5 years of academic/industry experience in antibody/protein engineering.
  • Extensive knowledge in target biology. Expertise in target validation studies.
  • Experience in developing biochemical assays, cell-based function assays is a plus
  • Extensive experience in bi/multi-specific antibody engineering.
  • Knowledge and experience in oncology and immunology drug discovery is a plus
  • Critical thinker with good time management and delivery focus, able to independently design, accurately interpret complex scientific experiments and data.
  • Highly motivated self-starter, work effectively and able to excel within a matrix organization.

If interested, please forward your resume to joycej@hutch-med.com

Responsibilities

  • Prepare process R&D related documents and reports to support IND and NDA.
  • Update technical documents and effectively communicate with process R&D team.
  • Support process R&D team to provide documentation for IND, NDA, IMPD, DSUR, annual report and etc.
  • Work effectively with regulatory, analytical R&D, formulation R&D to support all related documents preparation and updates.

 

Qualifications

  • Bachelor or Master degree in chemistry or pharmaceutical science.
  • Good understanding on process chemistry, pharmaceutical science, drug development.
  • Good English oral and writing skills.
  • Familiar with CFDA/FDA/EMA regulations and ICH guidelines, previous experiences with global filings are preferred.